Navid Sobhani

Research Scientist, Ph.D.


Curriculum vitae


[email protected]


Department of Cancer Biology

UT MD Anderson Cancer Center



Comment on my Nature book chapter "Biomarkers of Prediction of Immunotherapy and Updates on CTLA-4 Therapy"


October 07, 2023


- It provides a comprehensive overview of CTLA-4 inhibition as an immunotherapy approach, including insights into the structure, function, and mechanism of action of CTLA-4. This helps establish foundational knowledge on this important checkpoint inhibitor pathway.

- A wide range of cancers are discussed in terms of studies evaluating CTLA-4 inhibitors as monotherapy or in combination with other agents like anti-PD-1 inhibitors. This includes analyses of results from clinical trials, giving a good sense of the evidence base. 

- Both promising results and mixed/negative findings are presented objectively, showing an even-handed evaluation of the literature. This helps identify areas where more research is still needed.

- Biomarkers and platforms for predicting response to immunotherapy are thoroughly covered, highlighting emerging technologies that could help optimize patient selection. This focus on personalized medicine is important.

- References are comprehensive, including many recent studies, indicating the chapter thoroughly and up-to-date reviews the current state of knowledge on this topic. 

- The level of detail, inclusion of results data from trials, and discussion of ongoing studies provides useful information for researchers. It could also help clinicians stay abreast of new developments.

In summary, this is a well-structured, comprehensive review that synthesizes a large body of research on CTLA-4 inhibition. It establishes important mechanistic context while also giving a practical overview of applications across cancer types based on clinical evidence. This makes it a valuable resource.

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