The study aimed to investigate the correlation between the prognosis of pancreatic ductal adenocarcinoma (PDAC) patients and the presence of tumour infiltrating lymphocytes (TILs) and the expression of immune system genes.
The researchers examined intratumoural CD3+, CD8+, and CD20+ lymphocytes in PDAC patients who underwent pancreaticoduodenectomy and correlated the results with the gene expression profile using the NanoString nCounter analysis system. They identified 20 immune system genes that were differentially expressed in patients with a good prognosis compared to those with a worse prognosis.
The study found that higher levels of tumour infiltrating lymphocytes were present in samples from patients with a better prognosis. The expression levels of specific immune system genes were also associated with pancreatic adenocarcinoma prognosis. The authors suggested that this information could be useful in improving the selection of patients who are likely to respond well to immune inhibitors.
Overall, the study highlights the potential significance of tumour infiltrating lymphocytes and immune-related genes as predictors of outcome in pancreatic adenocarcinoma, providing insights that could contribute to the development of more effective treatment strategies for this challenging disease.
The researchers examined intratumoural CD3+, CD8+, and CD20+ lymphocytes in PDAC patients who underwent pancreaticoduodenectomy and correlated the results with the gene expression profile using the NanoString nCounter analysis system. They identified 20 immune system genes that were differentially expressed in patients with a good prognosis compared to those with a worse prognosis.
The study found that higher levels of tumour infiltrating lymphocytes were present in samples from patients with a better prognosis. The expression levels of specific immune system genes were also associated with pancreatic adenocarcinoma prognosis. The authors suggested that this information could be useful in improving the selection of patients who are likely to respond well to immune inhibitors.
Overall, the study highlights the potential significance of tumour infiltrating lymphocytes and immune-related genes as predictors of outcome in pancreatic adenocarcinoma, providing insights that could contribute to the development of more effective treatment strategies for this challenging disease.